Brief Information of the Compound and Protein
Compound Name
4-(4-{3-[4-(3,4-Dimethoxy-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
    Show/Hide
Canonical SMILES
COc1ccc(Nc2ncnc3cc(OCCCOc4ccc(-c5cssc5=S)cc4)c(OC)cc23)cc1OC
    Show/Hide
Compound Formula C29H27N3O5S3
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CL000077 Ba/F3 Mus musculus (Mouse)  3
1
GI50 = 830 nM
   TI
   LI
   LO
   TS
2
GI50 = 3390 nM
   TI
   LI
   LO
   TS
3
GI50 = 6350 nM
   TI
   LI
   LO
   TS
CL000324 NCI-H3255 Homo sapiens (Human)  1
1
GI50 = 8578 nM
   TI
   LI
   LO
   TS