Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
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 PubChem ID
CID: 16097523
SID: 24744062
Canonical SMILES
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)[nH]n1
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Compound Formula C17H19ClFN7O
Compound Structure
Protein Name
 Protein Info 
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000243 MCF-10A
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CL000028 PC-12
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 0.26 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Kd = 0.204 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.36 nM
2 Ki = 3.7 nM