Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid

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PubChem ID

CID: 9893571

SID: 123055315

Canonical SMILES	CC(C)c1onc(c1COc1ccc(\C=C\c2cccc(c2)C(O)=O)c(Cl)c1)-c1c(Cl)cccc1Cl Show/Hide
Compound Formula	C28H22Cl3NO4

Compound Structure

Protein Name

Protein Info

Bile acid receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group H

Nuclear hormone receptor subfamily 1 group H member 4

Uniprot ID

Q96RI1

Gene Name

NR1H4

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 400 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	EC50 = 65 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 90 nM	TI LI LO TS
2	EC50 = 95 nM	TI LI LO TS
3	EC50 = 231.5 nM	TI LI LO TS
4	EC50 = 260 nM	TI LI LO TS
5	EC50 = 550 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 12 nM	TI LI LO TS
2	EC50 = 26 nM	TI LI LO TS
3	EC50 = 30 nM	TI LI LO TS
4	EC50 = 35 nM	TI LI LO TS
5	EC50 = 70 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 510 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 20 nM	TI LI LO TS
CL000148	Huh-7 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 13.2 nM	TI LI LO TS

Biochemical Assays