Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(-)-(etorphine)

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PubChem ID

CID: 5288826

SID: 14897787

Canonical SMILES	CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O Show/Hide
Compound Formula	C17H19NO3

Compound Structure

Protein Name

Protein Info

Mu-type opioid receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Opioid receptor

Uniprot ID

P35372

Gene Name

OPRM1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000049	C6 Cell Line Info	Rattus norvegicus (Rat)	1
1	Ki = 1.7 nM	TI LI LO TS
CL000066	Chem-5 Cell Line Info	Rattus norvegicus (Rat)	1
1	Ki = 6.08 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	16
1	EC50 = 3.7 nM	TI LI LO TS
2	EC50 = 15.6 nM	TI LI LO TS
3	EC50 = 34 nM	TI LI LO TS
4	EC50 = 64 nM	TI LI LO TS
5	EC50 = 147 nM	TI LI LO TS
6	ED50 = 37 nM	TI LI LO TS
7	IC50 = 6.3 nM	TI LI LO TS
8	Ki = 0.88 nM	TI LI LO TS
9	Ki = 1.1 nM	TI LI LO TS
10	Ki = 1.92 nM	TI LI LO TS
11	Ki = 2.52 nM	TI LI LO TS
12	Ki = 2.55 nM	TI LI LO TS
13	Ki = 2.6 nM	TI LI LO TS
14	Ki = 4.2 nM	TI LI LO TS
15	Ki = 4.6 nM	TI LI LO TS
16	Ki = 17 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	6
1	EC50 = 4.7 nM	TI LI LO TS
2	EC50 = 5 nM	TI LI LO TS
3	EC50 = 10 nM	TI LI LO TS
4	EC50 = 379.6 nM	TI LI LO TS
5	EC50 = 380 nM	TI LI LO TS
6	Ki = 5.2 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 8.71 nM	TI LI LO TS
2	EC50 = 79.43 nM	TI LI LO TS
3	EC50 = 416.87 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 39.81 nM	TI LI LO TS
2	EC50 = 501.19 nM	TI LI LO TS
3	IC50 = 0.57 nM	TI LI LO TS
4	IC50 = 4.3 nM	TI LI LO TS
5	Ki = 2.2 nM	TI LI LO TS
6	Ki = 4 nM	TI LI LO TS
7	Ki = 4.19 nM	TI LI LO TS
CL000050	HEK293-A Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 6 nM	TI LI LO TS
2	EC50 = 6.4 nM	TI LI LO TS
3	EC50 = 7 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 410 nM
2	Ki = 0.53 nM
3	Ki = 1.1 nM
4	Ki = 1.8 nM
5	Ki = 2.84 nM
6	Ki = 3 nM
7	Ki = 3.96 nM
8	Ki = 17 nM
9	Ki = 38 nM

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han