Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Lumacaftor
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 PubChem ID
CID: 16678941
SID: 26654506
Canonical SMILES
Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O
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Compound Formula C24H18F2N2O5
Compound Structure
Protein Name
 Protein Info 
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
>
Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000535 CFBE41o-
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 2570.4 nM
   TI
   LI
   LO
   TS
2
Kd = 72800 nM
   TI
   LI
   LO
   TS
CL000259 FRT
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 2600 nM
2 Kd = 47800 nM