Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyrimidin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
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 PubChem ID
CID: 11741361
SID: 16847876
Canonical SMILES
Cc1cnc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
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Compound Formula C19H21ClF2N4O
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
EC50 = 389.05 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 4.677 nM
   TI
   LI
   LO
   TS
2
EC50 = 60.26 nM
   TI
   LI
   LO
   TS
3
EC50 = 245.47 nM
   TI
   LI
   LO
   TS
4
EC50 = 302 nM
   TI
   LI
   LO
   TS
5
Ki = 2.188 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 194.98 nM
   TI
   LI
   LO
   TS