Brief Information of the Compound and Protein
Compound Name
(S)-ethyl 2-((R)-(((2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
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PubChem ID
CID: 126629647
Canonical SMILES
CCOC(=O)[C@H](C)N[P@@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](Cl)(Br)[C@@H]1O)Oc1ccccc1
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Compound Formula C20H24BrClN3O9P
Compound Structure
Protein Name
RNA-directed RNA polymerase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
Q8JXU8
Gene Name
NS5B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 1190 nM
   TI
   LI
   LO
   TS
2
EC50 = 1210 nM
   TI
   LI
   LO
   TS