Brief Information of the Compound and Protein
Compound Name
US9546153, ex. 143
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PubChem ID
CID: 90155577
Canonical SMILES
CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]([C@H](O)CO)c1ccccc1
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Compound Formula C23H23N5O3S
Compound Structure
Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase IRAK family
Uniprot ID
Q9NWZ3
Gene Name
IRAK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4.7 nM
2 IC50 = 5 nM
3 IC50 = 300 nM