Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1,6-dimethyl-5-[2-piperidin-4-yl-7-(trifluoromethyl)indazol-5-yl]pyridin-2-one
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 PubChem ID
CID: 156010320
Canonical SMILES
Cc1c(ccc(=O)n1C)-c1cc(c2nn(cc2c1)C1CCNCC1)C(F)(F)F
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Compound Formula C20H21F3N4O
Compound Structure
Protein Name
 Protein Info 
Toll-like receptor 8
Protein Classification
Membrane receptor
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Toll-like and Il-1 receptors
Uniprot ID
Q9NR97
Gene Name
TLR8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CL000090 Schneider 2
 Cell Line Info 
Drosophila melanogaster (Fruit fly)  1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS