Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione

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PubChem ID

CID: 2477

SID: 14902734

Canonical SMILES	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 Show/Hide
Compound Formula	C21H31N5O2

Compound Structure

Protein Name

Protein Info

5-hydroxytryptamine receptor 1A

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Serotonin receptor

Uniprot ID

P08908

Gene Name

HTR1A

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 41 nM	TI LI LO TS
2	Ki = 20 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	5
1	EC50 = 15.14 nM	TI LI LO TS
2	EC50 = 38.02 nM	TI LI LO TS
3	EC50 = 72.44 nM	TI LI LO TS
4	Ki = 5.012 nM	TI LI LO TS
5	Ki = 21 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	Ki = 50 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	Ki = 12 nM	TI LI LO TS
2	Ki = 20 nM	TI LI LO TS
3	Ki = 21 nM	TI LI LO TS
4	Ki = 22 nM	TI LI LO TS
5	Ki = 32.2 nM	TI LI LO TS
6	Ki = 34.3 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 186.21 nM	TI LI LO TS

Biochemical Assays