Brief Information of the Compound and Protein
Compound Name
 Compound Info 
SID50106398
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 PubChem ID
CID: 139087706
SID: 15322134
Canonical SMILES
Cl.Cl.NCCc1c[nH]cn1
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Compound Formula C5H11Cl2N3
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  3
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
2
Ki = 158.49 nM
   TI
   LI
   LO
   TS
3
Ki = 218.78 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 33.88 nM
   TI
   LI
   LO
   TS
CL000903 HEK293-SF-hH4R-His6-CRE-Luc
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 16.98 nM
   TI
   LI
   LO
   TS
CL000909 HEK293T-SF-His6-CRE-Luc
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
Ki = 12.59 nM
   TI
   LI
   LO
   TS
2
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 12.59 nM