Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine
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 PubChem ID
CID: 2247
SID: 14760289
Canonical SMILES
COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1
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Compound Formula C28H31FN4O
Compound Structure
Protein Name
 Protein Info 
Potassium voltage-gated channel subfamily H member 2
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Voltage-gated potassium channel
Uniprot ID
Q12809
Gene Name
KCNH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 8 nM
   TI
   LI
   LO
   TS
3
IC50 = 2600 nM
   TI
   LI
   LO
   TS
4
IC50 = 2700 nM
   TI
   LI
   LO
   TS
5
Ki = 2.1 nM
   TI
   LI
   LO
   TS
6
Ki = 2.9 nM
   TI
   LI
   LO
   TS
7
Ki = 12.8 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 0.912 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1.9 nM
2 IC50 = 0.9 nM
3 IC50 = 1.5 nM
4 IC50 = 3.31 nM
5 IC50 = 10 nM
6 IC50 = 11.48 nM
7 Ki = 20 nM