Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6Hdibenzo[b,d]pyran

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PubChem ID

CID: 6918505

SID: 15247833

Canonical SMILES	CCCC(C)(C)c1ccc2[C@@H]3CC(C)=CC[C@H]3C(C)(C)Oc2c1 Show/Hide
Compound Formula	C22H32O

Compound Structure

Protein Name

Protein Info

Cannabinoid receptor 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Cannabinoid receptor

Uniprot ID

P34972

Gene Name

CNR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 4 nM	TI LI LO TS
2	Ki = 3.4 nM	TI LI LO TS
3	Ki = 8 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 391.1 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 81.8 nM	TI LI LO TS
2	IC50 = 550 nM	TI LI LO TS
3	Ki = 1.82 nM	TI LI LO TS
4	Ki = 3 nM	TI LI LO TS
5	Ki = 3.4 nM	TI LI LO TS
6	Ki = 140 nM	TI LI LO TS

Biochemical Assays