Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene

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PubChem ID

CID: 5311501

SID: 14782868

Canonical SMILES	Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 Show/Hide
Compound Formula	C27H26N2O3

Compound Structure

Protein Name

Protein Info

Cannabinoid receptor 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Cannabinoid receptor

Uniprot ID

P34972

Gene Name

CNR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	20
1	EC50 = 1.585 nM	TI LI LO TS
2	EC50 = 11.5 nM	TI LI LO TS
3	EC50 = 14.8 nM	TI LI LO TS
4	EC50 = 15.6 nM	TI LI LO TS
5	EC50 = 24.6 nM	TI LI LO TS
6	EC50 = 89.6 nM	TI LI LO TS
7	IC50 = 15.7 nM	TI LI LO TS
8	Ki = 0.3 nM	TI LI LO TS
9	Ki = 1.57 nM	TI LI LO TS
10	Ki = 1.6 nM	TI LI LO TS
11	Ki = 3.01 nM	TI LI LO TS
12	Ki = 3.1 nM	TI LI LO TS
13	Ki = 3.55 nM	TI LI LO TS
14	Ki = 4 nM	TI LI LO TS
15	Ki = 4.53 nM	TI LI LO TS
16	Ki = 4.6 nM	TI LI LO TS
17	Ki = 4.95 nM	TI LI LO TS
18	Ki = 6.31 nM	TI LI LO TS
19	Ki = 9.1 nM	TI LI LO TS
20	Ki = 70 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 0.47 nM	TI LI LO TS
2	IC50 = 8.9 nM	TI LI LO TS
3	Ki = 0.45 nM	TI LI LO TS
4	Ki = 8.57 nM	TI LI LO TS
CL000880	COS Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Ki = 2.1 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 0.39 nM	TI LI LO TS
2	EC50 = 86 nM	TI LI LO TS
3	Ki = 1.2 nM	TI LI LO TS
4	Ki = 2 nM	TI LI LO TS
5	Ki = 2.1 nM	TI LI LO TS
6	Ki = 3.7 nM	TI LI LO TS
7	Ki = 13 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	2
1	Ki = 3.7 nM	TI LI LO TS
2	Ki = 3.9 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	3
1	EC50 = 14 nM	TI LI LO TS
2	IC50 = 3.4 nM	TI LI LO TS
3	Ki = 2.512 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 2.7 nM
2	Ki = 0.28 nM
3	Ki = 0.3 nM
4	Ki = 1.3 nM
5	Ki = 1.7 nM
6	Ki = 2 nM
7	Ki = 2.2 nM
8	Ki = 2.9 nM
9	Ki = 3.1 nM
10	Ki = 3.73 nM
11	Ki = 9.1 nM
12	Ki = 20 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han