Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10017502, Example 4b
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 PubChem ID
CID: 118599727
Canonical SMILES
CNC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1
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Compound Formula C20H18FN3O5
Compound Structure
Protein Name
 Protein Info 
Mineralocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 2
Uniprot ID
P08235
Gene Name
NR3C2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000213 EA.hy 926
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 12.59 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CL000952 UAS-MR-bla HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 39.81 nM