Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10155972, Compound LM10
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 PubChem ID
CID: 135743630
SID: 125320180
Canonical SMILES
Fc1ccc2c(\C=C\c3nnn[nH]3)c[nH]c2c1
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Compound Formula C11H8FN5
Compound Structure
Protein Name
 Protein Info 
Tryptophan 2,3-dioxygenase
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P48775
Gene Name
TDO2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 398 nM
   TI
   LI
   LO
   TS
CL000784 P815B
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 1740 nM
   TI
   LI
   LO
   TS
CL000102 U-87MG ATCC
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
2
IC50 = 671 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 620 nM
2 IC50 = 2000 nM
3 Ki = 5500 nM