Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[(6R,7R)-7-(5-chloro-6-methyl-1H-indazol-4-yl)-2-[3-(dimethylamino)azetidin-1-yl]-6-methyl-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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 PubChem ID
CID: 139388571
Canonical SMILES
C[C@@H]1Cc2c(C[C@H]1c1c(Cl)c(C)cc3[nH]ncc13)nc(nc2N1CCN(CC1)C(=O)C=C)N1CC(C1)N(C)C
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Compound Formula C29H37ClN8O
Compound Structure
Protein Name
 Protein Info 
GTPase KRas
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
P01116
Gene Name
KRAS
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 126 nM
   TI
   LI
   LO
   TS
CL000268 NCI-H358
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 116 nM
   TI
   LI
   LO
   TS