Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US9243002, 88
    Show/Hide
 PubChem ID
CID: 90332545
Canonical SMILES
CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2Cn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
    Show/Hide
Compound Formula C32H24F2N4O4S
Compound Structure
Protein Name
 Protein Info 
RNA-directed RNA polymerase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
Q8JXU8
Gene Name
NS5B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7
 Cell Line Info 
Homo sapiens (Human)  8
1
EC50 = 2.2 nM
   TI
   LI
   LO
   TS
2
EC50 = 2.7 nM
   TI
   LI
   LO
   TS
3
EC50 = 3 nM
   TI
   LI
   LO
   TS
4
EC50 = 3.9 nM
   TI
   LI
   LO
   TS
5
EC50 = 5.1 nM
   TI
   LI
   LO
   TS
6
EC50 = 8.5 nM
   TI
   LI
   LO
   TS
7
EC50 = 9.5 nM
   TI
   LI
   LO
   TS
8
EC50 = 34 nM
   TI
   LI
   LO
   TS