Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US9243002, 82
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 PubChem ID
CID: 90341025
Canonical SMILES
CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2ccn3c(cc4c(F)cccc34)c2n1)-c1ccc(F)cc1
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Compound Formula C33H24F2N4O4S
Compound Structure
Protein Name
 Protein Info 
RNA-directed RNA polymerase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
Q8JXU8
Gene Name
NS5B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7
 Cell Line Info 
Homo sapiens (Human)  11
1
EC50 = 0.95 nM
   TI
   LI
   LO
   TS
2
EC50 = 1.2 nM
   TI
   LI
   LO
   TS
3
EC50 = 2.6 nM
   TI
   LI
   LO
   TS
4
EC50 = 2.9 nM
   TI
   LI
   LO
   TS
5
EC50 = 3.5 nM
   TI
   LI
   LO
   TS
6
EC50 = 4.8 nM
   TI
   LI
   LO
   TS
7
EC50 = 5.5 nM
   TI
   LI
   LO
   TS
8
EC50 = 6.3 nM
   TI
   LI
   LO
   TS
9
EC50 = 6.7 nM
   TI
   LI
   LO
   TS
10
EC50 = 11 nM
   TI
   LI
   LO
   TS
11
EC50 = 30 nM
   TI
   LI
   LO
   TS