Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one
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 PubChem ID
CID: 5073
SID: 14904216
Canonical SMILES
Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
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Compound Formula C23H27FN4O2
Compound Structure
Protein Name
 Protein Info 
Potassium voltage-gated channel subfamily H member 2
Protein Classification
Ion channel
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Voltage-gated ion channel
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Potassium channels
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Voltage-gated potassium channel
Uniprot ID
Q12809
Gene Name
KCNH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 151.36 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 163 nM
   TI
   LI
   LO
   TS
2
IC50 = 167.1 nM
   TI
   LI
   LO
   TS
3
IC50 = 581 nM
   TI
   LI
   LO
   TS
4
Ki = 920 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 162.18 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 147.91 nM
2 IC50 = 148 nM
3 IC50 = 167 nM
4 IC50 = 260 nM
5 IC50 = 778 nM
6 IC50 = 1070 nM
7 IC50 = 1330 nM