Brief Information of the Compound and Protein
Compound Name
BMS-907351
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PubChem ID
CID: 25102847
Canonical SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
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Compound Formula C28H24FN3O5
Compound Structure
Protein Name
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 19.86 nM
   TI
   LI
   LO
   TS
CL000413 MKN45 Homo sapiens (Human)  1
1
IC50 = 44.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.3 nM
2 IC50 = 1.4 nM
3 IC50 = 2.9 nM
4 IC50 = 3.2 nM
5 IC50 = 3.6 nM
6 IC50 = 3.7 nM
7 IC50 = 7.2 nM
8 IC50 = 8 nM
9 IC50 = 8.4 nM
10 IC50 = 19 nM
11 IC50 = 21 nM
12 IC50 = 34 nM
13 IC50 = 37.28 nM