Brief Information of the Compound and Protein
Compound Name
8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-2-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
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PubChem ID
CID: 70800874
Canonical SMILES
CNC(=O)c1c(oc2cc3N(C(CS(C)(=O)=O)COC(C)c3cc12)S(C)(=O)=O)-c1ccc(F)cc1
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Compound Formula C23H25FN2O7S2
Compound Structure
Protein Name
RNA-directed RNA polymerase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
Q8JXU8
Gene Name
NS5B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
2
EC50 = 51 nM
   TI
   LI
   LO
   TS
3
EC50 = 70 nM
   TI
   LI
   LO
   TS
4
EC50 = 134 nM
   TI
   LI
   LO
   TS