Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

CAS_3853

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PubChem ID

CID: 5311200

SID: 57304374

Canonical SMILES	Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1 Show/Hide
Compound Formula	C18H19ClN4

Compound Structure

Protein Name

Protein Info

D(4) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P21917

Gene Name

DRD4

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	6
1	EC50 = 27 nM	TI LI LO TS
2	Ki = 0.43 nM	TI LI LO TS
3	Ki = 0.6166 nM	TI LI LO TS
4	Ki = 0.62 nM	TI LI LO TS
5	Ki = 0.7 nM	TI LI LO TS
6	Ki = 0.91 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 42.66 nM	TI LI LO TS
2	IC50 = 93.33 nM	TI LI LO TS
3	IC50 = 144.54 nM	TI LI LO TS
4	IC50 = 162.18 nM	TI LI LO TS
5	IC50 = 1949.84 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 0.43 nM	TI LI LO TS
2	Ki = 2.239 nM	TI LI LO TS

Biochemical Assays