Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
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 PubChem ID
CID: 2733526
SID: 14853108
Canonical SMILES
CC\C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
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Compound Formula C26H29NO
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000168 AH109A-TC
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
IC50 = 2540 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 341 nM
   TI
   LI
   LO
   TS
2
IC50 = 622 nM
   TI
   LI
   LO
   TS
3
Ki = 31.19 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 1605 nM
   TI
   LI
   LO
   TS
2
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CL000644 MCF-7-2a
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CL000078 T-47D
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
2
IC50 = 100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 2540 nM
2 IC50 = 1.5 nM
3 IC50 = 8 nM
4 IC50 = 8.4 nM
5 IC50 = 24.55 nM
6 IC50 = 42 nM
7 IC50 = 60.9 nM
8 IC50 = 61 nM
9 IC50 = 69 nM
10 IC50 = 70 nM
11 IC50 = 100 nM
12 IC50 = 222 nM
13 IC50 = 622 nM
14 IC50 = 1000 nM