Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

3-HYDROXYTYRAMINE HYDROCHLORIDE

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PubChem ID

CID: 681

SID: 15170929

Canonical SMILES	NCCc1ccc(O)c(O)c1 Show/Hide
Compound Formula	C8H11NO2

Compound Structure

Protein Name

Protein Info

D(2) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P14416

Gene Name

DRD2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	12
1	EC50 = 36 nM	TI LI LO TS
2	EC50 = 43 nM	TI LI LO TS
3	EC50 = 183 nM	TI LI LO TS
4	EC50 = 209 nM	TI LI LO TS
5	EC50 = 218 nM	TI LI LO TS
6	EC50 = 227 nM	TI LI LO TS
7	EC50 = 240 nM	TI LI LO TS
8	EC50 = 376 nM	TI LI LO TS
9	Ki = 8 nM	TI LI LO TS
10	Ki = 48 nM	TI LI LO TS
11	Ki = 360 nM	TI LI LO TS
12	Ki = 450 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	5
1	EC50 = 0.69 nM	TI LI LO TS
2	EC50 = 0.99 nM	TI LI LO TS
3	EC50 = 6.7 nM	TI LI LO TS
4	EC50 = 40 nM	TI LI LO TS
5	EC50 = 140 nM	TI LI LO TS
CL000153	CHOP Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 7.7 nM	TI LI LO TS
2	EC50 = 65 nM	TI LI LO TS
3	Ki = 422 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	4
1	EC50 = 5 nM	TI LI LO TS
2	EC50 = 160 nM	TI LI LO TS
3	EC50 = 200 nM	TI LI LO TS
4	EC50 = 390 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	17
1	EC50 = 0.67 nM	TI LI LO TS
2	EC50 = 0.78 nM	TI LI LO TS
3	EC50 = 0.8 nM	TI LI LO TS
4	EC50 = 2.8 nM	TI LI LO TS
5	EC50 = 3.9 nM	TI LI LO TS
6	EC50 = 4.5 nM	TI LI LO TS
7	EC50 = 18 nM	TI LI LO TS
8	EC50 = 19 nM	TI LI LO TS
9	EC50 = 156 nM	TI LI LO TS
10	EC50 = 163 nM	TI LI LO TS
11	EC50 = 226 nM	TI LI LO TS
12	Ki = 2.9 nM	TI LI LO TS
13	Ki = 8.73 nM	TI LI LO TS
14	Ki = 16 nM	TI LI LO TS
15	Ki = 260 nM	TI LI LO TS
16	Ki = 2100 nM	TI LI LO TS
17	Ki = 3690 nM	TI LI LO TS
CL000041	LTK- Cell Line Info	Mus musculus (Mouse)	3
1	EC50 = 170 nM	TI LI LO TS
2	Ki = 1.89 nM	TI LI LO TS
3	Ki = 759 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 3.981 nM	TI LI LO TS

Biochemical Assays

1	Ki = 1.89 nM
2	Ki = 17 nM
3	Ki = 20 nM
4	Ki = 34 nM
5	Ki = 42 nM
6	Ki = 572 nM
7	Ki = 1100 nM
8	Ki = 1900 nM
9	Ki = 7940 nM
10	Ki = 15000 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han