Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
    Show/Hide
 PubChem ID
CID: 2771
SID: 14826333
Canonical SMILES
CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
    Show/Hide
Compound Formula C20H21FN2O
Compound Structure
Protein Name
 Protein Info 
Sodium-dependent serotonin transporter
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Uniprot ID
P31645
Gene Name
SLC6A4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 59 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 5.81 nM
   TI
   LI
   LO
   TS
3
IC50 = 6.27 nM
   TI
   LI
   LO
   TS
4
IC50 = 19 nM
   TI
   LI
   LO
   TS
5
Ki = 1.6 nM
   TI
   LI
   LO
   TS
6
Ki = 4.38 nM
   TI
   LI
   LO
   TS
7
Ki = 32.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13.41 nM
2 IC50 = 90 nM
3 Ki = 1.6 nM