Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

14C-5-hydroxy tryptamine creatinine disulfate

Show/Hide

PubChem ID

CID: 5202

SID: 15120541

Canonical SMILES	NCCc1c[nH]c2ccc(O)cc12 Show/Hide
Compound Formula	C10H12N2O

Compound Structure

Protein Name

Protein Info

5-hydroxytryptamine receptor 2C

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Serotonin receptor

Uniprot ID

P28335

Gene Name

HTR2C

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	7
1	EC50 = 1.63 nM	TI LI LO TS
2	EC50 = 1.7 nM	TI LI LO TS
3	EC50 = 24 nM	TI LI LO TS
4	EC50 = 25 nM	TI LI LO TS
5	Ki = 8.3 nM	TI LI LO TS
6	Ki = 214 nM	TI LI LO TS
7	Ki = 445 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 0.09 nM	TI LI LO TS
2	EC50 = 0.21 nM	TI LI LO TS
3	EC50 = 0.41 nM	TI LI LO TS
4	EC50 = 25.12 nM	TI LI LO TS
5	EC50 = 190.55 nM	TI LI LO TS
6	Ki = 20 nM	TI LI LO TS
7	Ki = 50.12 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 51.29 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1.25 nM	TI LI LO TS

Biochemical Assays