Brief Information of the Compound and Protein
Compound Name
 Compound Info 
6,6-dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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 PubChem ID
CID: 127034802
Canonical SMILES
CC1(C)c2[nH]c3cc(ccc3c2C(=O)c2ccc(cc12)C1CCN(CC2CCOCC2)CC1)C#N
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Compound Formula C30H33N3O2
Compound Structure
Protein Name
 Protein Info 
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000320 NCI-H3122
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 17.9 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.4 nM
2 IC50 = 3.7 nM
3 IC50 = 3.9 nM
4 IC50 = 7.6 nM
5 IC50 = 8.1 nM
6 IC50 = 8.5 nM
7 IC50 = 38.1 nM