Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

1,3-dipropyl-8-cyclopentylxanthine

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PubChem ID

CID: 1329

SID: 12014525

Canonical SMILES	CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CCCC1 Show/Hide
Compound Formula	C16H24N4O2

Compound Structure

Protein Name

Protein Info

Adenosine receptor A1

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Nucleotide-like receptor (family A GPCR)

Adenosine receptor

Uniprot ID

P30542

Gene Name

ADORA1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	13
1	EC50 = 1.52 nM	TI LI LO TS
2	IC50 = 0.5 nM	TI LI LO TS
3	Ki = 0.5 nM	TI LI LO TS
4	Ki = 0.9 nM	TI LI LO TS
5	Ki = 1.09 nM	TI LI LO TS
6	Ki = 2.13 nM	TI LI LO TS
7	Ki = 2.2 nM	TI LI LO TS
8	Ki = 3.2 nM	TI LI LO TS
9	Ki = 3.9 nM	TI LI LO TS
10	Ki = 4 nM	TI LI LO TS
11	Ki = 6.1 nM	TI LI LO TS
12	Ki = 6.5 nM	TI LI LO TS
13	Ki = 12.02 nM	TI LI LO TS
CL000939	CHO-A1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 3.2 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 933.25 nM	TI LI LO TS
2	Ki = 39.81 nM	TI LI LO TS
3	Ki = 95 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 0.5888 nM	TI LI LO TS
2	Ki = 1.6 nM	TI LI LO TS

Biochemical Assays