Brief Information of the Compound and Protein
Compound Name
 Compound Info 
14C-5-hydroxy tryptamine creatinine disulfate
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 PubChem ID
CID: 5202
SID: 15120541
Canonical SMILES
NCCc1c[nH]c2ccc(O)cc12
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Compound Formula C10H12N2O
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 7
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P34969
Gene Name
HTR7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 0.25 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.47 nM
   TI
   LI
   LO
   TS
3
Ki = 0.17 nM
   TI
   LI
   LO
   TS
4
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
2
EC50 = 15 nM
   TI
   LI
   LO
   TS
3
EC50 = 70 nM
   TI
   LI
   LO
   TS
4
Kd = 3.98 nM
   TI
   LI
   LO
   TS
5
Ki = 2.12 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
2
Ki = 1.4 nM
   TI
   LI
   LO
   TS
3
Ki = 2.1 nM
   TI
   LI
   LO
   TS
4
Ki = 6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.29 nM
2 IC50 = 0.49 nM
3 IC50 = 0.61 nM
4 IC50 = 1.5 nM
5 Ki = 0.11 nM
6 Ki = 0.13 nM
7 Ki = 0.22 nM
8 Ki = 3.162 nM
9 Ki = 4 nM
10 Ki = 8.1 nM