Brief Information of the Compound and Protein
Compound Name
 Compound Info 
14C-5-hydroxy tryptamine creatinine disulfate
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 PubChem ID
CID: 5202
SID: 15120541
Canonical SMILES
NCCc1c[nH]c2ccc(O)cc12
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Compound Formula C10H12N2O
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 6
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P50406
Gene Name
HTR6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 130 nM
   TI
   LI
   LO
   TS
3
Ki = 33 nM
   TI
   LI
   LO
   TS
4
Ki = 61 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 43.6 nM
   TI
   LI
   LO
   TS
2
Ki = 33 nM
   TI
   LI
   LO
   TS
3
Ki = 75 nM
   TI
   LI
   LO
   TS
4
Ki = 78 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 125.89 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 27.5 nM
2 IC50 = 100 nM
3 IC50 = 180 nM
4 IC50 = 200 nM
5 IC50 = 262 nM
6 Ki = 50 nM
7 Ki = 65 nM
8 Ki = 70 nM
9 Ki = 84 nM
10 Ki = 93 nM
11 Ki = 100 nM