Brief Information of the Compound and Protein
Compound Name
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
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PubChem ID
CID: 5278396
SID: 14781018
Canonical SMILES
O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
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Compound Formula C21H17NO3S2
Compound Structure
Protein Name
Serine-protein kinase ATM
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
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Atypical protein kinase PIKK family
Uniprot ID
Q13315
Gene Name
ATM
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000007 HT-29 Homo sapiens (Human)  1
1
IC50 = 1220 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 2 nM
2 IC50 = 12.9 nM
3 IC50 = 13 nM
4 IC50 = 14 nM
5 IC50 = 250 nM
6 Ki = 2.2 nM