Brief Information of the Compound and Protein
Compound Name
 Compound Info 
BMS-907351
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 PubChem ID
CID: 25102847
Canonical SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
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Compound Formula C28H24FN3O5
Compound Structure
Protein Name
 Protein Info 
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  5
1
GI50 = 10 nM
   TI
   LI
   LO
   TS
2
GI50 = 50 nM
   TI
   LI
   LO
   TS
3
GI50 = 890 nM
   TI
   LI
   LO
   TS
4
GI50 = 910 nM
   TI
   LI
   LO
   TS
5
IC50 = 180 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 811 nM
   TI
   LI
   LO
   TS
CL000425 TT
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 120 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.4 nM
2 IC50 = 4 nM
3 IC50 = 5 nM
4 IC50 = 5.2 nM
5 IC50 = 7 nM
6 IC50 = 8 nM
7 IC50 = 10.1 nM
8 IC50 = 13 nM
9 IC50 = 14 nM
10 IC50 = 16 nM
11 IC50 = 18 nM
12 IC50 = 37 nM
13 IC50 = 45 nM
14 IC50 = 76 nM
15 IC50 = 132 nM
16 IC50 = 230 nM
17 IC50 = 358 nM
18 IC50 = 1500 nM