Brief Information of the Compound and Protein
Compound Name
N-[1-[6-[(4-chlorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl]acetamide
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PubChem ID
CID: 127042856
Canonical SMILES
CC(=O)NC1CCN(CC1)c1nc(nc2CCN(Cc3ccc(Cl)cc3)Cc12)-c1ccccn1
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Compound Formula C26H29ClN6O
Compound Structure
Protein Name
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
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Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 707.95 nM
   TI
   LI
   LO
   TS
CL000259 FRT Rattus norvegicus (Rat)  1
1
EC50 = 700 nM
   TI
   LI
   LO
   TS