Brief Information of the Compound and Protein
Compound Name
2-[4-[6-[(4-methoxyphenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]acetamide
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PubChem ID
CID: 127041885
Canonical SMILES
COc1ccc(CN2CCc3nc(nc(N4CCN(CC(N)=O)CC4)c3C2)-c2ccccn2)cc1
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Compound Formula C26H31N7O2
Compound Structure
Protein Name
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
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Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 = 10900 nM
   TI
   LI
   LO
   TS
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 2290.87 nM
   TI
   LI
   LO
   TS
CL000259 FRT Rattus norvegicus (Rat)  1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS