Brief Information of the Compound and Protein
Compound Name
N,N-dimethyl-2-[4-[2-pyridin-2-yl-6-(thiophen-3-ylmethyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]ethanamine
    Show/Hide
PubChem ID
CID: 127041886
Canonical SMILES
CN(C)CCN1CCN(CC1)c1nc(nc2CCN(Cc3ccsc3)Cc12)-c1ccccn1
    Show/Hide
Compound Formula C25H33N7S
Compound Structure
Protein Name
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
>
Other ion channel
>
Chloride channel
>
Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 199.53 nM
   TI
   LI
   LO
   TS
CL000259 FRT Rattus norvegicus (Rat)  1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS