Brief Information of the Compound and Protein
Compound Name
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
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PubChem ID
CID: 121513893
Canonical SMILES
CN(C)CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
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Compound Formula C26H29N7O2
Compound Structure
Protein Name
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  7
1
GI50 = 3 nM
   TI
   LI
   LO
   TS
2
GI50 = 4 nM
   TI
   LI
   LO
   TS
3
GI50 = 11 nM
   TI
   LI
   LO
   TS
4
GI50 = 16 nM
   TI
   LI
   LO
   TS
5
GI50 = 33 nM
   TI
   LI
   LO
   TS
6
GI50 = 170 nM
   TI
   LI
   LO
   TS
7
GI50 = 220 nM
   TI
   LI
   LO
   TS
CL000071 MOLM-13 Homo sapiens (Human)  2
1
EC50 < 30 nM
   TI
   LI
   LO
   TS
2
EC50 = 100 nM
   TI
   LI
   LO
   TS
CL000408 MOLM-14 Homo sapiens (Human)  1
1
EC50 < 30 nM
   TI
   LI
   LO
   TS
CL000091 MV4-11 Homo sapiens (Human)  1
1
EC50 < 30 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 40 nM