Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SCH 23390)
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 PubChem ID
CID: 3036864
SID: 14751202
Canonical SMILES
CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
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Compound Formula C17H18ClNO
Compound Structure
Protein Name
 Protein Info 
D(1A) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P21728
Gene Name
DRD1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 2.52 nM
   TI
   LI
   LO
   TS
2
Ki = 0.8 nM
   TI
   LI
   LO
   TS
3
Ki = 1.24 nM
   TI
   LI
   LO
   TS
4
Ki = 1.69 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.66 nM
2 IC50 = 0.74 nM
3 IC50 = 0.82 nM
4 IC50 = 0.96 nM
5 Ki = 0.11 nM
6 Ki = 0.2 nM
7 Ki = 0.3 nM
8 Ki = 0.38 nM
9 Ki = 0.4266 nM
10 Ki = 1.4 nM