Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
    Show/Hide
 PubChem ID
CID: 5265
SID: 14903329
Canonical SMILES
Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
    Show/Hide
Compound Formula C23H26FN3O2
Compound Structure
Protein Name
 Protein Info 
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 0.36 nM
   TI
   LI
   LO
   TS
2
Ki = 0.12 nM
   TI
   LI
   LO
   TS
3
Ki = 0.25 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 97 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 93.2 nM
   TI
   LI
   LO
   TS
2
Ki = 0.33 nM
   TI
   LI
   LO
   TS
3
Ki = 0.48 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 1.31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.25 nM
2 Ki = 0.32 nM