Brief Information of the Compound and Protein
Compound Name
N-[(3R,4R)-1-[6-[(1-ethyl-3-methoxypyrazol-4-yl)amino]-9-methylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
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PubChem ID
CID: 118073630
Canonical SMILES
CCn1cc(Nc2nc(nc3n(C)cnc23)N2C[C@@H](F)[C@@H](C2)NC(=O)C=C)c(OC)n1
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Compound Formula C19H24FN9O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 194 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CL000324 NCI-H3255 Homo sapiens (Human)  1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS