Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one

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PubChem ID

CID: 60795

SID: 15103350

Canonical SMILES	Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show/Hide
Compound Formula	C23H27Cl2N3O2

Compound Structure

Protein Name

Protein Info

D(2) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P14416

Gene Name

DRD2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	12
1	IC50 = 7.6 nM	TI LI LO TS
2	Ki = 0.2 nM	TI LI LO TS
3	Ki = 0.38 nM	TI LI LO TS
4	Ki = 0.45 nM	TI LI LO TS
5	Ki = 0.48 nM	TI LI LO TS
6	Ki = 0.52 nM	TI LI LO TS
7	Ki = 0.53 nM	TI LI LO TS
8	Ki = 0.54 nM	TI LI LO TS
9	Ki = 1.8 nM	TI LI LO TS
10	Ki = 3.9 nM	TI LI LO TS
11	Ki = 4 nM	TI LI LO TS
12	Ki = 5.012 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	4
1	EC50 = 1 nM	TI LI LO TS
2	EC50 = 130 nM	TI LI LO TS
3	EC50 = 740 nM	TI LI LO TS
4	EC50 = 1100 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	17
1	EC50 = 4.8 nM	TI LI LO TS
2	EC50 = 8.7 nM	TI LI LO TS
3	EC50 = 14.9 nM	TI LI LO TS
4	EC50 = 17.5 nM	TI LI LO TS
5	EC50 = 19.4 nM	TI LI LO TS
6	EC50 = 38.9 nM	TI LI LO TS
7	EC50 = 158.49 nM	TI LI LO TS
8	EC50 > 5000 nM	TI LI LO TS
9	Ki = 0.3 nM	TI LI LO TS
10	Ki = 0.34 nM	TI LI LO TS
11	Ki = 0.343 nM	TI LI LO TS
12	Ki = 0.48 nM	TI LI LO TS
13	Ki = 0.8 nM	TI LI LO TS
14	Ki = 2.6 nM	TI LI LO TS
15	Ki = 2.8 nM	TI LI LO TS
16	Ki = 3.1 nM	TI LI LO TS
17	Ki = 4.5 nM	TI LI LO TS
CL000883	HTLA Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 4 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 4 nM
2	IC50 = 17.2 nM
3	Ki = 0.8 nM
4	Ki < 1 nM
5	Ki = 1.6 nM
6	Ki = 1.82 nM
7	Ki = 3.3 nM
8	Ki = 8 nM
9	Ki = 9.7 nM

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han