Brief Information of the Compound and Protein
Compound Name
 Compound Info 
CHEBI:66901
    Show/Hide
 PubChem ID
CID: 16220172
SID: 24902571
Canonical SMILES
CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
    Show/Hide
Compound Formula C24H28N2O3
Compound Structure
Protein Name
 Protein Info 
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
>
Other ion channel
>
Chloride channel
>
Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000259 FRT
 Cell Line Info 
Rattus norvegicus (Rat)  3
1
EC50 = 49 nM
   TI
   LI
   LO
   TS
2
EC50 = 70 nM
   TI
   LI
   LO
   TS
3
EC50 = 131 nM
   TI
   LI
   LO
   TS
CL000805 HBE1
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 22 nM
   TI
   LI
   LO
   TS
2
EC50 = 34 nM
   TI
   LI
   LO
   TS
3
EC50 = 68 nM
   TI
   LI
   LO
   TS
4
EC50 = 236 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 3 nM
2 EC50 = 236 nM