Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenylthio)-2-methylpropanoic acid

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PubChem ID

CID: 3392731

SID: 14835703

Canonical SMILES	CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show/Hide
Compound Formula	C29H46N2O3S

Compound Structure

Protein Name

Protein Info

Peroxisome proliferator-activated receptor alpha

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group C

Nuclear hormone receptor subfamily 1 group C member 1

Uniprot ID

Q07869

Gene Name

PPARA

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 1 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	4
1	EC50 = 200 nM	TI LI LO TS
2	EC50 = 230 nM	TI LI LO TS
3	EC50 = 250 nM	TI LI LO TS
4	EC50 = 2080 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	EC50 = 6 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 15.4 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	EC50 = 0.89 nM	TI LI LO TS
2	EC50 = 5.4 nM	TI LI LO TS
3	EC50 = 6.5 nM	TI LI LO TS
4	EC50 = 21 nM	TI LI LO TS
5	EC50 = 26 nM	TI LI LO TS
6	EC50 = 200 nM	TI LI LO TS
CL000050	HEK293-A Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 200 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 7 nM	TI LI LO TS
2	EC50 = 9 nM	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 6.5 nM	TI LI LO TS

Biochemical Assays