Brief Information of the Compound and Protein
Compound Name
N-[4-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]butyl]-5-[(dimethylamino)methyl]imidazo[1,2-a]pyridine-2-carboxamide
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PubChem ID
CID: 117870140
Canonical SMILES
CN(C)Cc1cccc2nc(cn12)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
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Compound Formula C28H39F3N8O
Compound Structure
Protein Name
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  5
1
Ki = 12 nM
   TI
   LI
   LO
   TS
2
Ki = 16 nM
   TI
   LI
   LO
   TS
3
Ki = 24 nM
   TI
   LI
   LO
   TS
4
Ki = 27 nM
   TI
   LI
   LO
   TS
5
Ki = 44 nM
   TI
   LI
   LO
   TS
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS