Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8748608, 34
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 PubChem ID
CID: 25141534
SID: 56468910
Canonical SMILES
OC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl
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Compound Formula C23H26Cl2N4O2
Compound Structure
Protein Name
 Protein Info 
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 30 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 495 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 29.9 nM
   TI
   LI
   LO
   TS
2
Ki = 1.39 nM
   TI
   LI
   LO
   TS
3
Ki = 1.88 nM
   TI
   LI
   LO
   TS
4
Ki = 1.9 nM
   TI
   LI
   LO
   TS