Brief Information of the Compound and Protein
Compound Name
4-[(4aR,7aR)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6-yl]-6-cyclopentylpyrimidin-2-amine
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PubChem ID
CID: 66740470
Canonical SMILES
Nc1nc(cc(n1)N1C[C@H]2NCCO[C@@H]2C1)C1CCCC1
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Compound Formula C15H23N5O
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Kd = 125.89 nM
   TI
   LI
   LO
   TS
2
Ki = 56 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 > 10000 nM