Brief Information of the Compound and Protein
Compound Name
 Compound Info 
12-chloro-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-amine
    Show/Hide
 PubChem ID
CID: 54753437
SID: 131479524
Canonical SMILES
CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)cnc3oc12
    Show/Hide
Compound Formula C14H15ClN6O
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 9 nM
2 Ki = 9.4 nM