Brief Information of the Compound and Protein
Compound Name
4-[(1R)-1-[8-tert-butyl-2-(3,5-dichlorophenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-en-4-yl]propyl]-N-(2H-tetrazol-5-ylmethyl)benzamide
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Canonical SMILES
CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
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Compound Formula C30H35Cl2N7O2
Compound Structure
Protein Name
Glucagon receptor
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
>
Peptide receptor (family B GPCR)
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Glucagon-like receptor
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Glucagon receptor
Uniprot ID
P47871
Gene Name
GCGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
2
IC50 = 270 nM
   TI
   LI
   LO
   TS