Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
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 PubChem ID
CID: 4521392
SID: 87231679
Canonical SMILES
NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1
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Compound Formula C22H16N4O3
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000775 CHO/IR
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CL000150 HaCaT
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 172 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 1542 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 66 nM
2 IC50 = 70 nM
3 IC50 = 94 nM
4 IC50 = 125 nM
5 Kd = 170 nM
6 Ki = 17 nM