Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate
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 PubChem ID
CID: 45378252
SID: 93369784
Canonical SMILES
CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](CCNC(=O)OCc1ccccc1)C(=O)NO
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Compound Formula C22H25N3O7S
Compound Structure
Protein Name
 Protein Info 
Disintegrin and metalloproteinase domain-containing protein 17
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M12B subfamily
Uniprot ID
P78536
Gene Name
ADAM17
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000476 A2774
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
2
IC50 = 419 nM
   TI
   LI
   LO
   TS
CL000072 A2780
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 1436 nM
   TI
   LI
   LO
   TS
CL000084 SK-OV-3
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 966 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.6 nM